秦建华,张敏,于浩,李中玉.人体器官芯片[J].中国科学院院刊,2017,(12):1281-1289.

人体器官芯片

Human Organs-on-a-chip
作者
秦建华
中国科学院大连化学物理研究所 大连 160023;中国科学院大学 未来技术学院 北京 100049
Qin Jianhua
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 160023, China;School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
张敏
中国科学院大连化学物理研究所 大连 160023
Zhang Min
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 160023, China
于浩
中国科学院大连化学物理研究所 大连 160023
Yu Hao
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 160023, China
李中玉
中国科学院大连化学物理研究所 大连 160023
Li Zhongyu
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 160023, China
中文关键词
         器官芯片;微流控;生物传感;疾病模型;药物评价
英文关键词
        organs-on-a-chip;microfluidic;biosensing and devices;disease model;drug evaluation
中文摘要
        人体器官芯片是一门新兴的前沿科学技术,也是一门典型的多学科交叉汇聚技术,对人类健康和生物产业发展具有重要战略意义,吸引了来自政府、科学界和产业界的关注,被2016年达沃斯世界经济论坛列为"十大新兴技术"之一。人体器官芯片指的是一种在载玻片大小芯片上构建的器官生理微系统,包含有活体细胞、组织界面、生物流体和机械力等器官微环境关键要素。它可在体外模拟人体不同组织器官的主要结构功能特征和复杂的器官间联系,用以预测人体对药物或外界不同刺激产生的反应,在生命科学和医学研究、新药研发、个性化医疗、毒性预测和生物防御等领域具有广泛应用前景。文章概述性介绍了人体器官芯片的起源、国际发展态势和研究进展,并对其面临的挑战和未来发展趋势予以展望。
英文摘要
        Human organs-on-a-chip is a newly emerging and frontier technology involving with different disciplines in recent years. It refers to a biomimetic microphysiological system created on a bioengineered microfluidic device, representing the organ-level functional units. It can recapitulate the physiologically relevant structures and functions of the organs, as well as the interaction between multiple organs as in vivo, thereby offering alternative models for predicting human responses to various drugs and environmental stimulus. Organs-on-a-chip technology has wide application potentials in many fields such as life science, drug discovery, personalized medicine, food/environment monitoring and biological defense et al. The emergence of this technology has attracted much attention from the government, scientific community and industry due to its unique features and promising applications. It has been selected as the "Top Ten Emerging Technologies" by the World Economic Forum in 2016. Considering the huge market in industrialization, several companies have started to get involved in this area and the pace of industrialization has been accelerated rapidly. Human organs-on-a-chip scan not only reproduce the physiopathology of human organ, but it can also enable researchers to witness and study various biological behaviors of the organism in an unprecedented way. It could be used to analyze the occurrence and development of the complicated human diseases in a new perspective, and is expected to bring about a revolution in the traditional fields including biomedical research, drug testing, personalized medicine, toxicity prediction, biodefensive fields. Here, we summarize the origins, development, and application fields of human organson-a-chip technology. We also discuss the existing challenges and give perspectives for the development of this technology in future.
DOI10.16418/j.issn.1000-3045.2017.12.002
作者简介
秦建华 中科院大连化学物理所研究员、微流控芯片中心主任,辽宁省微流控芯片重点实验室主任,大连市微流控芯片工程中心主任。先后任本领域国际刊物Biomicrofluidics副主编和Lab on a Chip副主编,2014年入选英国皇家化学会会士。主要研究领域:微流控系统与生物医学交叉学科研究,人体器官芯片构筑基础及其应用。E-mail:jhqin@dicp.ac.cn
Qin Jianhua Received M.D.from China Medical University,and Ph.D.from Chinese Academy of Sciences (CAS),respectively.She did postdoctoral research at Universityof Toronto in Canada and worked as visiting professor at the University of Hong Kong,China.She is the director of Microfluidics Research Center in Dalian Institute of Chemical Physics,CAS.She was elected as the Fellow of Royal Society of Chemistry (FRSC) in 2014.She served as the associate editor of Lab on a Chip and Biomicrofluidics.She has published more than 100 peer reviewed papers and 2 books.She held 70 patents till now.Her current research interests lie in the development of organs-on-chips technology for applications in disease modeling and drug testing.E-mail:jhqin@dicp.ac.cn
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