张先恩.生物传感发展50年及展望[J].中国科学院院刊,2017,(12):1271-1280.

生物传感发展50年及展望

Biosensors: 50 Years Development and Future Perspectives
作者
张先恩
中国科学院生物物理研究所 生物大分子国家重点实验室 中国科学院生物大分子卓越中心 北京 100101
Zhang Xian-En
National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
中文关键词
         生物传感;大健康;穿戴式;无创分析;活体测定;分子生物传感;纳米生物传感;高时空分辨
英文关键词
        biosensors;One-Health;wearable;noninvasive;in vivo analysis;molecular biosensors;nanobiosensors;ultra-high temporal-spatial resolution
中文摘要
        生物传感器是由生物元件与物理和化学换能器件构成的分析装置,属于典型的交叉学科和汇聚技术。生物传感器具有快速、准确、简便的特点,并借助微阵列平台技术(生物芯片)实现了高通量分析,在生命科学研究、疾病诊断和监控、生物过程控制、农业与食品安全、环境质量监控、生物安全与生物安保等领域有广阔的应用前景。经历50年后,生物传感进入一个新的蓬勃发展阶段,主要驱动因素是大健康、物联网、大数据等概念的提出与实施;研究热点包括穿戴式和便携式,即时检测(POCT)、无创分析、活体测定、在线检测、现场监测、超高时空分辨和单细胞生物学应用等。不同的应用场景存在不同的技术难题,其中生物元件的稳定性是共性问题,尚待攻克。中国学者在生物传感领域的研究论文影响力总体上已经进入国际第一方阵,下一步目标是学术上实现卓越和引领,并大幅提升全球市场开发能力,贡献大健康。
英文摘要
        Biosensors are the devices made of biological elements and physical or chemical transducers for fast and specific determination of biological or related substances, of which is a typical convergence technology. Biosensors have broad application prospects in life science research, disease diagnosis and control, bioengineering process control, agriculture and food security, environmental quality monitoring, biosafety and biosecurity, etc. 50 years after its birth, biosensor technology has entered a new phase of vigorous development. The main driving forces are the introduction and implementation of the concepts of One-Health, Internet of Things, and big data. Research hot topics include wearable and portable biosensing for point-of-care testing (POCT) and home care, noninvasive analysis, in vivo analysis, online analysis, field test, ultra-high temporal-spatial resolution, and single-cell biology. Technical challenges vary in different application scenarios, among which the thermal stability of biosensor recognition elements is a major concern, which is to be overcome by finding new solution. Literature statistics indicates that the Chinese researchers as a whole have made dramatic advances during the past two decades and now ranks top in terms of both paper number in total and the number of high impact papers. However, these do not mean that China is taking the lead in the field. Achieving academic excellence and exploring the global market will be the next goals for the Chinese researchers and industrial sector.
DOI10.16418/j.issn.1000-3045.2017.12.001
作者简介
张先恩 中科院生物物理所研究员。1993年在中科院武汉病毒研究所晋升研究员,从事生物传感器、纳米生物学和分析微生物研究,发表论文240篇(SCI收录200篇),出版生物传感和生物芯片相关专著3本。曾在科技部基础研究司从事基础研究宏观管理。目前兼任中国生物工程学会副理事长,亚洲生物技术协会(AFOB)顾问和纳米生物技术、生物传感与生物芯片分会共同主席、亚太经合组织(APEC)首席科学顾问会议中国代表(2013、2015和2016年)、国家"973"计划专家顾问组副组长。2015年被加拿大Alberta大学授予名誉科学博士学位。E-mail:zhangxe@ibp.ac.cn
Zhang Xian-En Distinguished professor in the Institute of Biophysics,Chinese Academy of Sciences (CAS).He became a full professor in the Institute of Virology,CAS,in 1993,specializing in biosensors,nanobiology,and analytical microbiology,and has published about 240 peerreviewed papers and three books.He currently serves as the vice president of the Chinese Society of Biotechnology,co-chair of the Division of Nanobiotechnology,Biosensors and Biochips of the Asian Federation of Biotechnology (AFOB),executive chief editor of Chinese Journal of Biotechnology,editorial member or advisor for 6 other scientific journals.From 2002 to 2013,Dr.Zhang served as the director general of the Basic Research Department,Ministry of Science and Technology (MOST),dedicating himself to the macro management of science development in China.He has been serving as the Chinese representative of the APEC Meeting of Chief Science Advisors or Equivalents since 2013(except for 2014) and deputy head of the Expert Advisory Group of the National "973" Program.In 2015,he was awarded an Honorary Doctor of Science Degree by the University of Alberta,Canada.E-mail:zhangxe@ibp.ac.cn
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